MCU-INDEPENDENT CA2+ UPTAKE MEDIATES MITOCHONDRIAL CA2+ OVERLOAD AND NECROTIC CELL DEATH IN A MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human mayfire nectarine diseases.Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis.The mitochondrial Ca

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Optimization of hoisting parameters in a multi-rope friction mine hoist based on the multi-source coupled vibration characteristics of hoisting catenaries

To avoid catenary 910-005270 collision in a multi-rope friction mine hoist, in this study, the relevant hoisting parameters based on the multi-source coupled vibration characteristics of hoisting catenaries are optimized.First, the multi-source coupled vibration characteristics of hoisting catenaries were investigated based on an established theore

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Care pathways for dementia: current perspectives

Kritika Samsi, Jill ManthorpeSocial Care Workforce Research Unit, King’s College London, London, UKAbstract: 910-005270 Uncertainty appears to typify the experience of living with dementia.With an uncertain illness trajectory and unpredictable levels of deterioration and stability in symptoms, people with a diagnosis of dementia may live with

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Prototipe Sistem Informasi Retailer Industri Kreatif Di Kota Solo

Solo is a cultural city.in addition solo has some business actors in the arts and cultural arts until now still exist in production.The problems faced by UKM craft art and culture here is the lack of marketing media, therefore making the difficulty of handicraft products known by the public.Marketing media utilized include brochures, pamphlets and

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